Each component listed below should have both data figures cut and pasted from your sources as well as written interpretations of the data.

Each component listed below should have both data figures cut and pasted from your sources as well as written interpretations of the data.

Do not include data you do not understand; you should be as concise as possible with your interpretations.

Data Sections

Disease Gene (Human and homolog)(20 points)
Structure: exon/intron structure (numbers as well as a picture), # exons, chromosome

location number as well as a picture, length of the gene in nucleotides or base pairs (6 points).

Transcript: length of coding regions in nucleotides or base pairs, length of both 3’ and 5’ UTRs, # splice variants, transcription start site (5 points).

Homolog: picture of homologous gene, name of species of homologous gene, level of

homology between the human gene and the homolog (i.e %), chromosome location of homolog and number of chromosomes of in the species the homologous gene is from (5 points).

Flanking genes: in both the human and the homologous gene (this means the names of four genes)(4 points).

Protein (15 points)
Structure: 1° (include the primary sequence), 2° (from protein modeling software), 3° (from protein modeling software), 4° (if applicable); known and predicted functional domain(s). You may create one model that fulfills both the 2° and 3° structure. You do not need to include a picture or model of any 4° sequence, a description is sufficient (5 points).

Interacting partners: other proteins, RNAs, DNAs, ligands (5 points).

Function: What is the role of the protein made by this gene? What pathway is it involved in? Where is it located in the cell (do not say everywhere!)? Is there a predominant process (like embryogenesis, etc.) or cell type it functions in? (5 points)

Explanation & Answer

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