MULTIPLE MYELOMA CAN RESULT IN A NUMBER OF PATHOPHYSIOLOGICAL AND PARANEOPLASTIC CONDITIONS IN THE CANINE AND FELINE PATIENT. FOR EACH OF THESE CONDITIONS, DESCRIBE WHY THESE CHANGES OCCUR, THE RESULTING CLINICAL SYNDROME, AND APPROPRIATE MANAGEMENT OF THESE CLINICAL EFFECTS.

MULTIPLE MYELOMA CAN RESULT IN A NUMBER OF PATHOPHYSIOLOGICAL AND PARANEOPLASTIC CONDITIONS IN THE CANINE AND FELINE PATIENT. FOR EACH OF THESE CONDITIONS, DESCRIBE WHY THESE CHANGES OCCUR, THE RESULTING CLINICAL SYNDROME, AND APPROPRIATE MANAGEMENT OF THESE CLINICAL EFFECTS.

4. Multiple myeloma can result in a number of pathophysiological and paraneoplastic
conditions in the canine and feline patient. For each of these conditions, describe why
these changes occur, the resulting clinical syndrome, and appropriate management of
these clinical effects. Include in your answer an estimate of how frequently each
condition occurs in dogs and cats. (30 marks)
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Veterinary Oncology Paper 2 Page 4 of 5
© 2016 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
5. Mammary neoplasia
Answer all parts of this question:
a) Compare and contrast the reported prognostic factors for canine and feline
mammary cancers. Include in your answer at least five (5) factors for both the
canine and feline disease. (5 marks)
b) A referring veterinarian seeks your opinion as to whether ovariohysterectomy is
indicated in a nine-year-old female dog scheduled for excision of a mammary
mass later the same day. Relate the available literature to this case, and provide
an appropriate rationale for the advice you would provide in this instance.
(10 marks)
c) Adjuvant chemotherapy is frequently used in multimodal treatment of canine and
feline mammary carcinomas. With reference to current literature, discuss the use
of adjuvant chemotherapy for both canine and feline mammary carcinomas, and
comment on the justification for each protocol or agent considered. (15 marks)
6. Toceranib
Answer all parts of this question:
a) Describe the mechanism of action of toceranib phosphate and explain how
cancer cells develop resistance to the effect(s) of this drug. (8 marks)
b) List the potential adverse effects of this medication, and explain why these
adverse effects may occur. (8 marks)
c) With reference to current literature, discuss the role of toceranib in the
management of canine and feline tumours. (14 marks)
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Veterinary Oncology Paper 2 Page 5 of 5
© 2016 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 208
7. Discuss prognostic factors for osteosarcoma in dogs including how each factor
specifically relate to survival time. For each factor provide at least one (1) reference
from veterinary literature. (30 marks)
8. Compare and contrast canine multicentric, gastrointestinal and epitheliotropic
lymphoma. Your answer should address the diagnosis and management of each
condition. (30 marks)

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