Report of the British Society for Antimicrobial Chemotherapy Initiative The Urgent Need: regenerating antibacterial drug discovery development

Report of the British Society for Antimicrobial Chemotherapy Initiative The Urgent Need: regenerating antibacterial drug discovery development

Source material Page 36 Working Party Membership Page 39

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Report of the British Society for Antimicrobial Chemotherapy Initiative The Urgent Need: regenerating antibacterial drug discovery development

“Antibiotic resistance – one of the three greatest threats to human health”, World Health Organisation, 2009

INTRODUCTION The British Society for Antimicrobial Chemotherapy is gravely concerned that the relentless rise in antibiotic

resistance, occurring at a time when pharmaceutical companies are disinvesting in the discovery and

development of antibacterial agents, will have severe and harmful effects on global health and our ability to

treat infections in hospitals and the community. The antibiotic pipeline is almost empty, yet the need for new

antibiotics to treat the increasing number of drug resistant infections continues to rise.

The models by which antibacterial agents are discovered and subsequently brought to market no longer

appear to be as effective as they once were. The magnitude of the problem faced is aptly demonstrated by

the IDSA 2004 Report Bad Bugs, No Drugs, which reports on sixteen new antibacterial agents being approved

and brought to market between 1983-1987, compared with the estimate that between only two and four new

antibacterial agents will reach market between 2008-2012. It is by no means clear if even these will address

the current clinical issues.

The Urgent Need initiative was established in response to these concerns, to identify barriers discouraging

participation in antibacterial drug discovery research, and to consider what opportunities exist to re-stimulate interest in the field, possibly through public / private partnership initiatives.

Our initiative is not unique, but it is an important part of a growing international movement that recognizes

the need for, and demands, action before the global medical community is faced with the unthinkable – a

post-antibiotic era where the treatment of infections, from the common to complex is no longer possible.

Looking at the three major components required to bring antibacterial agents to market – research, regulation

and economics – this report records the discussions held at three expert evidence sessions. It does not seek

simply to reiterate problems that have been rehearsed, recorded and reported so many times before, but to

identify practical solutions that can be developed, applied and implemented, using existing systems for

research, regulation and pricing,

Explanation & Answer

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