Summarizes a selection of Internet resources for conducting a clinical trial.1Department of Anesthesia, Hamilton Health Sciences, Hamilton, ON, Canada 2Department of Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Summarizes a selection of Internet resources for conducting a clinical trial.1Department of Anesthesia, Hamilton Health Sciences, Hamilton, ON, Canada
2Department of Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

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Tutorial

The Internet and Clinical Trials: Background, Online Resources, Examples and Issues

James Paul1,2, MSc, MD; Rachael Seib1,2, MA; Todd Prescott1,2, BSc

1Department of Anesthesia, Hamilton Health Sciences, Hamilton, ON, Canada
2Department of Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Corresponding Author:
James Paul, MSc, MD

Department of Anesthesia
Hamilton Health Sciences
Hamilton General Site
237 Barton St East
Hamilton, ON L8L 2X2
Canada
Phone: +1 905 527 4322 ext 46698
Fax: +1 905 577 8023
Email: james_paul [at] sympatico.ca

ABSTRACT
Both the Internet and clinical trials were significant developments in
the latter half of the twentieth century: the Internet revolutionized
global communications and the randomized controlled trial provided a
means to conduct an unbiased comparison of two or more treatments. Large
multicenter trials are often burdened with an extensive development
time and considerable expense, as well as significant challenges in
obtaining, backing up and analyzing large amounts of data. Alongside the
increasing complexities of the modern clinical trial has grown the
power of the Internet to improve communications, centralize and secure
data as well as to distribute information. As more and more clinical
trials are required to coordinate multiple trial processes in real time,
centers are turning to the Internet for the tools to manage the
components of a clinical trial, either in whole or in part, to produce
lower costs and faster results. This paper reviews the historical
development of the Internet and the randomized controlled trial,
describes the Internet resources available that can be used in a
clinical trial, reviews some examples of online trials and describes the
advantages and disadvantages of using the Internet to conduct a
clinical trial. We also extract the characteristics of the 5 largest
clinical trials conducted using the Internet to date, which together
enrolled over 26000 patients.
(J Med Internet Res 2005;7(1):e5)
doi:10.2196/jmir.7.1.e5

KEYWORDS

Clinical trials; randomized controlled trial; Internet

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Introduction
Both the Internet and clinical trials were significant developments in
the latter half of the 20th century: the Internet revolutionized global
communications and the randomized controlled trial (RCT) provided a
means to conduct an unbiased comparison of two or more treatments. This
paper reviews the historical development of the Internet and the
randomized controlled trial, describes the Internet resources available
that can be used in a clinical trial, reviews some examples of online
trials and describes the advantages and disadvantages of using the
Internet to conduct a clinical trial.

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