THE REASON WHY SOME HUMAN TUMOURS ARE LOCALLY CONTROLLED BY RADIOTHERAPY AND OTHERS ARE NOT REMAINS ONE OF THE KEY QUESTIONS IN THE RADIOBIOLOGY OF CANCER TREATMENT
THE REASON WHY SOME HUMAN TUMOURS ARE LOCALLY CONTROLLED BY RADIOTHERAPY AND OTHERS ARE NOT REMAINS ONE OF THE KEY QUESTIONS IN THE RADIOBIOLOGY OF CANCER TREATMENT
The reason why some human tumours are locally controlled by radiotherapy and others
are not remains one of the key questions in the radiobiology of cancer treatment. Give
an account of the various factors thought to be responsible for this difference in
radiation response.
2 Repopulation of cells after exposure to multiple doses of photons has been the subject
of considerable interest in radiotherapy since it was found that the proliferation of
surviving cells between successive fractions of radiation may be a determinant in
tumour control. Discuss the biologic characteristics of the types of tumour in which this
process has been observed. What is the radiobiological basis for the adoption of altered
fractionation regimes that are presently being utilised to overcome repopulation?
3 Discuss the rationale and applications of Dose-Volume-Histograms. What are their
radiobiological limitations?
4 The late effects of radiotherapy observed in children treated for cancer suggest that
certain tissues/organs are highly susceptible to damage. Describe the cell populations
involved, and discuss the mechanisms thought to be responsible for the effects
manifested.
5 Write short notes on any three of the following:
a) Radiation effects on the kidney
b) Radiation-induced apoptosis
c) Fluorescent in situ hybridisation
d) Target Cell Theory
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