Which of the following are characteristic of a hormone?

Which of the following are characteristic of a hormone?

Which of the following are characteristic of a hormone? (Select all that apply.) Give a rationale for each of your choices:
Hormones have specific rates and rhythms of secretion.
Hormones operate independent of feedback systems.
Hormones affect only cells with appropriate receptors.
Hormones are excreted by the kidneys.
Hormones are excreted by the liver.
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