Why is it important to learn how to read medical studies?How to Evaluate a Clinical Study: Guidelines to Help Understand Published Research

Why is it important to learn how to read medical studies?How to Evaluate a Clinical Study: Guidelines to Help Understand Published Research

Science is a work in progress. Every day, promising studies are released and new treatments are approved. But how can you evaluate whether the information you’re reading is relevant to your own health or to that of a patient, friend, or family member?

The newly emerging field of evidence-based medicine provides a set of straightforward guidelines for evaluating the data presented in published clinical studies. But since these studies don’t come with a set of instructions on how to understand them, the following is a set of criteria you can use to help evaluate what it is you’re reading.

Why is it important to learn how to read medical studies? Isn’t that knowledge that your doctor should have?

We believe educating patients on how to be their own best advocate is important because no one medical provider can know everything about a particular disease. By better understanding medical evidence, patients can (1) be better critical evaluators, (2) help others understand the science, and (3) be a more active team member when working with doctors to make treatment decisions.

Not all studies are well designed, or even well written. Study authors will sometimes make claims or recommendations not supported by the data. And often there is a filter of conflicting interests, often from drug companies or the media, which stands between you and the study itself. This filter can misinterpret or misrepresent the facts.

For many of us, when reading a medical study, we often read what we want to see. Our eyes are drawn first to the conclusions presented in a study’s abstract, a summary usually printed at the front. Often, we want to know how our health can benefit from this study right now. But before accepting the abstract’s conclusions at face value, we suggest the following:

First, go to the very end of the study, just before the references section, and look for a very short paragraph usually titled “Disclosures” or “Conflicts of Interest” to find out who funded the study. Pharmaceutical industry-funded trials often tend to be biased or over-interpretive of the true results. A meta-analysis published this year in the Journal of the American Medical Association (JAMA) found that industry-sponsored trials were 3.6 times more likely to show positive results, in favor of their product. (Bekelman, 2003)

Second, examine the study authors. Do they have the credentials or experience to properly conduct the study? The most important credential is actual clinical experience in the question being investigated.

Third, go beyond just the abstract to read the details of how the study was conducted. An average of 30 to 40% of published studies misrepresent the actual findings in the abstract, according to a recent critical analysis of six major medical journals. (Pitkin, 1999) Look carefully at the section usually titled” Materials & Methods.” While reading this section, ask yourself the following questions:

» Are the patients in the study closely matched to you in terms of age, gender, and specific medical problem?
» Were patients randomly assigned to the different treatment groups being compared?
» Was the trial double-blinded (neither patients nor doctors knew whether patients were receiving the treatment or placebo)?

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